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Alain Lafeuillade
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Cell-to-cell Spread of HIV Keeps Viral Reservoir Going Despite ART

Posted on Friday, 19 August 2011 in Fundamental Science

Researchers at the California Institute of Technology (Caltech) believe they have begun to decode how a reservoir of infection can persist in HIV-positive populations.

Their work is published ahead of print in the August 17, 2011 online issue of Nature:

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10347.html

The research team proposes that a type of HIV infection that uses infected cells to get close to uninfected cells and then discharge a large load of virus on them, may be the reason small populations of HIV-infected cells persist on effective ART.

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Alain Lafeuillade
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HIV Reservoirs Research Will Help Finding a Cure

Posted on Tuesday, 02 August 2011 in Fundamental Science

The quest toward finding a cure for HIV continues in earnest, and the scientific and medical communities alike are beginning to seriously whisper amongst themselves that a cure is just around the corner

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Alain Lafeuillade
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Tracking HIV in its Final Refuge

Posted on Friday, 29 July 2011 in Fundamental Science

Researchers are whittling down the places for HIV to hide, and the general consensus is that it's just a matter of time before a cure is found.  HIV is in its final refuge.

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Alain Lafeuillade
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Potential Strategies for an HIV Infection Cure

Posted on Tuesday, 21 June 2011 in Fundamental Science

Lafeuillade A. Potential Strategies for an HIV Infection Cure. HIV Clinical Trials 2011; 12 (3):121-30

http://thomasland.metapress.com/content/a01734v2v1232247/?p=84991f2f8c7149fcb20ee073f69bd48c&pi=0

Abstract: Despite long-term viral suppression with antiretroviral therapy (ART), HIV persists in reservoirs and sanctuary sites. Lifelong therapy is therefore necessary, leading to problems of compliance, toxicity, and cost. Over the last few years, important advances have been made in our understanding of the composition and the maintenance mechanisms of the HIV reservoir. Although complete viral eradication is currently out of reach, a growing number of scientists think that a "functional" cure is achievable. This situation would combine no disease progression, no virus transmission, and a life expectancy close to uninfected individuals in the absence of ART. At acute HIV infection, ART increases the frequency of sustained viremia control after its discontinuation, compared with the natural history of untreated disease. For patients at the chronic stage of HIV infection, ART alone is insufficient to clear viral reservoirs and new molecules intended to purge this reservoir or gene therapy approaches are warranted. This search for a cure needs innovation, audaciousness, and coordination. It also needs political, institutional, and private commitments for funding, which by now are severely lacking.

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Double-edged HIV-specific CD4+ T Cells?

Posted on Wednesday, 26 January 2011 in Fundamental Science

Recent findings suggest that HIV persistence in 'Elite Controllers' is driven by the strong specific CD4+ T cell response that allows these patients to remain stable.

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Dr Anthony Fauci Interview

Posted on Wednesday, 29 December 2010 in Fundamental Science

Do not miss this article.

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